Hierarchical modularity in human brain functional networks

Hierarchical Modularity in Human Brain Functional Networks

The idea that complex systems have a hierarchical modular organization originated in the early 1960s and has recently attracted fresh support from quantitative studies of large scale, real-life networks. Here we investigate the hierarchical modular (or "modules-within-modules") decomposition of human brain functional networks, measured using functional magnetic resonance imaging in 18 healthy v...

Hierarchical functional modularity in the resting-state human brain.

Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in the brain functional connectivity (BFC) map have highlighted the BFC's small-world topology. Modularity, a more advanced topological property, has been hypothesized to be evolutionary advantageous, contribut...

Functional Annotation of Hierarchical Modularity

In biological networks of molecular interactions in a cell, network motifs that are biologically relevant are also functionally coherent, or form functional modules. These functionally coherent modules combine in a hierarchical manner into larger, less cohesive subsystems, thus revealing one of the essential design principles of system-level cellular organization and function-hierarchical modul...

Modelling hierarchical structure in functional brain networks.

In this work, we focus on a complex-network approach for the study of the brain. In particular, we consider functional brain networks, where the vertices represent different anatomical regions and the links their functional connectivity. First, we build these networks using data obtained with functional magnetic resonance imaging. Then, we analyse the main characteristics of these complex netwo...

Hierarchical Organization of Modularity in Metabolic Networks